An enabled gRPC channel can be used to send and receive messages. A disabled channel cannot. Disabling a channel causes all gRPC method flow services exposed on that channel to become unavailable to any gRPC client. When you disable a gRPC channel, the gRPC server rejects any new requests and in-flight requests likely end with an error, though this is dependent on the programming language of the protocol buffer compiler plug-ins used to create the gRPC client.