The Data Source may receive a GDSN Item Registry Response, if applicable. After an item has been added or an existing item is modified (wherein GPC code, cancel date, or discontinued date is updated), IM sends a Registry Catalogue Item (RCI) message to the Global Registry. On successful receipt of a response from the Global Registry, IM Updates the item information, generates a GDSN Item Registry Response, and sends the response to the data source. An entry will also be sent to the Data Source's Worklist. This is a second response to the item maintenance request and is a response sent in addition to the Catalogue Response of type item. Since the Global Registry update process is asynchronous, the RCI process is managed independent of the Item load process of IM.